EPS4.06 Alterations in incretin and somatostatin levels by glucose tolerance status in people with cystic fibrosis

Objectives: Insulin deficiency in cystic fibrosis (CF) leads to CF related diabetes (CFRD), and dysregulation of other enteroendocrine hormones may further impair insulin secretion CF. This study investigated whether glucose intolerance was associated with altered incretin or somatostatin adults Methods: We conducted a cross-sectional using multiple-sample oral tolerance tests (OGTTs) at the Copenhagen Center, Denmark. Samples were analyzed for total gastric inhibitory polypeptide (GIP), glucagon-like peptide-1 (GLP-1), somatostatin, participants categorized by their status. assessed 0–120 minutes net incremental area under curve (iAUC) above baseline incretins 0–60 iAUC somatostatin. Results: included 93 data. Of these, data available 70 participants. Both AUC0–120 GIP GLP1 higher among those CFRD than NGT (16 ng/mL/min [5; 27] vs. 27 [16; 38], p = 0.04) (435 pmol/L/min [32; 839] 773 [420; 1,126], 0.04). However, there no linear association between iAUC0–120 any incretins. The iAUC0–60 – 164 [–368; 38] NGT, while it 2 [–75; 79] CFRD. Moreover, tended be positively status (p-value trend: 0.07). Conclusion: People did not seem have insufficient levels during an OGTT and, fact, seemed compensatory increase levels. worsening tolerance, which might suggest relative suppression impaired tolerance.